More than 13,500 bottles of a commonly prescribed blood pressure medicine have been recalled across the United States after the tablets failed required dissolution testing. Patients taking chlorthalidone are being advised to check their medication details and speak with a pharmacist or doctor before making any changes to treatment.

A nationwide recall involving 13,567 bottles of chlorthalidone 25 mg tablets has raised concerns about the quality and effectiveness of a medicine widely used to manage high blood pressure and fluid retention.

The voluntary recall was initiated by Inventia Healthcare Limited on 3 September 2026, and the U.S. Food and Drug Administration (FDA) classified the action as a Class II recall on 17 September 2026.

The reason for the recall is that the affected tablets failed dissolution specifications. Dissolution testing is an important quality check used to determine whether a tablet breaks down and releases its active ingredient properly.

If a medicine does not dissolve as expected, there can be concerns about whether the correct amount of the active ingredient becomes available for absorption.

The FDA’s Class II classification means that exposure to or use of the affected product may cause temporary or medically reversible health consequences, while the likelihood of serious harm is considered remote. Recent reporting identifies the recalled product as a 100-tablet bottle of chlorthalidone 25 mg, batch RISA24002, with an expiry date of April 2027.

Chlorthalidone Recall: Key Facts at a Glance

If you or someone in your household takes chlorthalidone, these are the important details to check:

• Medicine: Chlorthalidone Tablets, USP
• Strength: 25 mg
• Manufacturer: Inventia Healthcare Limited
• Quantity recalled: 13,567 bottles
• Bottle size: 100 tablets
• NDC: 64980-599-01
• Affected batch: RISA24002
• Expiry date: April 2027
• Recall reason: Failed dissolution specifications
• Distribution: Nationwide in the United States
• Recall classification: FDA Class II
• Recall status: Ongoing

The current recall should not be confused with an earlier chlorthalidone recall from June 2026 involving different batches. That earlier action covered 11,460 bottles, including batches RISA24001 and RISB24002.

Which Chlorthalidone Bottles Are Affected?

The most recent recall concerns Chlorthalidone Tablets USP, 25 mg, supplied in 100-tablet bottles.

Patients should check the information printed on their pharmacy label or original medicine packaging.

Look specifically for:

• NDC: 64980-599-01
• Batch/Lot: RISA24002
• Expiry: 04/2027
• Strength: 25 mg

It is important to remember that not every bottle of chlorthalidone has been recalled.

A medicine recall normally applies to specific products, strengths, package sizes and batches. Therefore, simply taking chlorthalidone does not automatically mean that your prescription is part of this recall.

If you cannot find the batch number or are unsure whether your tablets are included, contact the pharmacy that supplied the medicine.

Why Did the Chlorthalidone Tablets Fail Testing?

The recall was linked to a failure to meet the required dissolution specifications.

Dissolution testing looks at how a tablet releases its active ingredient after it is exposed to fluid under controlled laboratory conditions.

This matters because a tablet needs to release its medicine in a predictable way for the body to absorb the active ingredient properly.

A failure does not necessarily mean that every tablet will cause harm. However, it can raise concerns about whether the medicine will provide the expected treatment effect.

For someone taking chlorthalidone to control high blood pressure, reduced or inconsistent drug availability could potentially make blood pressure management more difficult.

The FDA’s Class II designation reflects the regulator’s classification of the potential health consequences and does not mean that serious injury is expected in every person who used the recalled medicine.

What Is Chlorthalidone Used For?

Chlorthalidone is a diuretic, sometimes called a “water tablet” or “water pill”.

It is commonly prescribed to:

• Lower high blood pressure.
• Help the kidneys remove excess salt and water.
• Reduce fluid retention in certain medical conditions.
• Support long-term blood pressure management.

According to MedlinePlus, chlorthalidone works by helping the kidneys remove unnecessary water and salt from the body through urine.

Because blood pressure treatment often requires consistent daily medication, patients should not suddenly stop taking chlorthalidone without medical advice.

What Should You Do If You Take Chlorthalidone?

If you regularly take chlorthalidone, there is no need to panic.

Instead, take a few practical steps.

1. Check your medicine bottle

Look for the:

• Medicine name.
• Strength.
• NDC number.
• Batch or lot number.
• Expiry date.

Compare these details with the recall information.

2. Contact your pharmacist

If your medicine appears to match the recalled batch, contact your pharmacist as soon as possible.

Your pharmacist can confirm whether your particular supply is affected and explain how to obtain an appropriate replacement.

3. Speak with your doctor if necessary

Your doctor can advise whether you should temporarily use another medicine or continue treatment while a replacement is arranged.

4. Do not stop your blood pressure medicine by yourself

This is particularly important.

Stopping a prescribed blood pressure medicine suddenly can interfere with blood pressure control. The American Heart Association advises patients to take their medicines properly and work with their healthcare professional when managing high blood pressure.

5. Keep monitoring your blood pressure

If you have a home blood pressure monitor, continue taking readings according to your healthcare professional’s instructions.

Keep a written or digital record of your readings and share unusual or consistently higher results with your healthcare team.

High Blood Pressure Remains a Major Health Concern

The medication recall comes at a time when high blood pressure continues to affect a large proportion of adults in the United States.

The American Heart Association reported in May 2026 that approximately 125.9 million U.S. adults, or 47.3%, were living with high blood pressure.

The organisation also reported particularly high rates among Black American adults, with hypertension affecting 62.3% of non-Hispanic Black men and 59.2% of non-Hispanic Black women.

These figures highlight why maintaining reliable blood pressure treatment and regularly checking blood pressure readings are so important.

High blood pressure often develops without obvious warning signs, which means someone can have elevated readings without feeling unwell.

Why High Blood Pressure Can Be Dangerous

When high blood pressure remains uncontrolled for a long period, it can put additional strain on the:

• Heart
• Brain
• Blood vessels
• Kidneys
• Eyes

Untreated hypertension is associated with an increased risk of serious conditions, including heart disease, stroke, heart failure and kidney disease.

This is one reason patients prescribed blood pressure medication should work closely with their healthcare team, particularly if their medicine supply is affected by a recall.

What Symptoms Should You Watch For?

One of the most important facts about hypertension is that most people do not experience clear symptoms when their blood pressure is high.

A headache or feeling dizzy does not reliably tell you whether your blood pressure is elevated.

The best way to know your blood pressure is to measure it properly.

According to the 2025 American Heart Association/American College of Cardiology guideline:

• Normal: below 120/80 mmHg
• Elevated: 120–129 systolic and below 80 diastolic
• Stage 1 hypertension: 130–139 systolic or 80–89 diastolic
• Stage 2 hypertension: 140 or higher systolic or 90 or higher diastolic

A single high reading does not necessarily establish a diagnosis, so repeated measurements and professional assessment are important.

When Is Blood Pressure an Emergency?

A blood pressure reading of more than 180/120 mmHg requires prompt attention.

If you obtain a reading this high, repeat the measurement after at least one minute.

If it remains very high and you also experience warning symptoms such as:

• Chest pain
• Shortness of breath
• Weakness or numbness
• Difficulty speaking
• Changes in vision
• Severe or concerning symptoms

seek emergency medical assistance.

Do not wait for symptoms to become severe before seeking help.

Simple Daily Habits That Can Help Lower Blood Pressure

Medication is only one part of managing hypertension.

The 2025 AHA/ACC blood pressure guideline recommends several lifestyle measures that can help prevent or manage high blood pressure.

1. Follow a DASH-Style Eating Pattern

The DASH diet, or Dietary Approaches to Stop Hypertension, focuses on foods such as:

• Vegetables
• Fruit
• Whole grains
• Beans and other legumes
• Nuts and seeds
• Lean proteins
• Low-fat or fat-free dairy products

It also encourages reducing foods high in sodium and unhealthy fats.

You do not necessarily need expensive specialist foods. Simple meals based around vegetables, beans, whole grains and lean proteins can support a heart-friendly eating pattern.

2. Reduce Sodium

Too much sodium can contribute to higher blood pressure.

The 2025 guideline recommends keeping sodium intake below 2,300 mg per day, while moving towards an ideal target of around 1,500 mg per day for adults where appropriate.

Practical steps include:

• Checking food labels.
• Choosing lower-sodium packaged foods.
• Eating fewer heavily processed foods.
• Limiting salty snacks.
• Using herbs, garlic, lemon, spices and other seasonings instead of relying heavily on salt.

3. Stay Physically Active

Regular physical activity can help improve blood pressure and overall cardiovascular health.

Activities can include:

• Walking
• Cycling
• Swimming
• Dancing
• Gardening
• Strength exercises
• Other activities that you can safely maintain

The 2025 guideline recommends regular moderate physical activity as part of blood pressure management.

If you have existing medical conditions or have not exercised for a long time, speak with a healthcare professional about an appropriate level of activity.

4. Maintain a Healthy Weight Where Appropriate

For people who are overweight or living with obesity, even modest weight loss can contribute to better blood pressure control.

The AHA notes that losing around 5% of body weight can support overall health and help lower blood pressure.

5. Limit Alcohol

Alcohol can affect blood pressure, particularly when consumed heavily.

The American Heart Association says heavy drinking and binge drinking are consistently associated with worse cardiovascular outcomes, including hypertension, stroke and heart failure.

Reducing alcohol consumption can therefore be an important part of a broader heart-health plan.

6. Avoid Tobacco and Nicotine

Smoking and nicotine can raise blood pressure and damage cardiovascular health.

Quitting smoking is one of the important steps people can take to protect their heart and blood vessels.

7. Pay Attention to Sleep and Stress

Poor sleep and ongoing stress can also make healthy blood pressure management more difficult.

The AHA recommends healthy sleep, physical activity and stress-management approaches as part of broader cardiovascular health.

People who snore loudly, wake frequently during the night or regularly feel exhausted despite getting enough time in bed may wish to discuss possible sleep problems with a healthcare professional.

What About Potassium and Salt Substitutes?

Potassium-rich foods can be useful for some people trying to manage blood pressure.

However, potassium supplements and potassium-containing salt substitutes are not suitable for everyone.

People with kidney disease or those taking certain medicines may need to restrict potassium or monitor their potassium levels.

For this reason, speak with your doctor or pharmacist before making a major change involving potassium supplements or salt substitutes.

Home Blood Pressure Monitoring Can Be Helpful

Checking blood pressure at home can provide useful information about how well treatment is working.

For more reliable readings:

• Use a validated upper-arm blood pressure monitor.
• Follow the monitor’s instructions carefully.
• Sit quietly before taking the measurement.
• Keep your arm supported.
• Take readings consistently.
• Record your results.
• Share the readings with your healthcare professional.

The 2025 AHA/ACC guideline specifically highlights home blood pressure monitoring as a useful part of confirming and managing hypertension.

The Bottom Line

The recall of 13,567 bottles of chlorthalidone 25 mg tablets is an important reminder for patients to know exactly which medicine they are taking and to check the batch information when a recall is announced.

The latest recall involves Inventia Healthcare’s 25 mg chlorthalidone tablets, NDC 64980-599-01, batch RISA24002, expiring in April 2027. The recall was initiated in September 2026 after the tablets failed dissolution specifications and was subsequently classified by the FDA as Class II.

If you take chlorthalidone:

• Check your bottle and batch information.
• Ask your pharmacist whether your medicine is affected.
• Do not stop prescribed treatment without professional advice.
• Arrange a replacement if your supply is recalled.
• Continue monitoring your blood pressure.
• Seek urgent medical help for dangerously high readings accompanied by serious symptoms.

Most importantly, a medication recall does not mean patients should suddenly abandon their blood pressure treatment. The safest approach is to identify the affected batch, speak with a pharmacist or healthcare professional and make a supervised plan for replacement treatment.

Managing blood pressure is a long-term process involving the right medication, regular monitoring and healthy daily habits. Together, these steps can help protect the heart, brain, kidneys and blood vessels.

Important Health Disclaimer

This article is for general information and should not replace advice from a qualified doctor, pharmacist or other healthcare professional. If you believe you have a recalled medicine, contact your pharmacist or prescriber for advice before changing or stopping treatment.

References and Sources

1. U.S. Food and Drug Administration (FDA) — Drug recall and enforcement information concerning Inventia Healthcare’s chlorthalidone tablets.
2. MedlinePlus / U.S. National Library of Medicine — Chlorthalidone drug information and uses.
3. American Heart Association — 2025 High Blood Pressure Guideline and recommendations for blood pressure management.
4. American Heart Association — High blood pressure information and guidance for Black communities.
5. American Heart Association — Lifestyle measures for managing blood pressure, including diet, exercise, weight, sleep and alcohol.
6. American Heart Association — Alcohol consumption and cardiova

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